Genetic Algorithm for Predicting Primary Imatinib Resistance in Locally Advanced or Metastatic Gastrointestinal Stromal Tumors

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms, primarily driven by KIT or PDGFRA mutations. While tyrosine kinase inhibitors (TKIs), such as imatinib, have transformed treatment, resistance remains a significant challenge. Alternative TKIs offer options but with increased toxicity and inconsistent efficacy. This study investigates artificial intelligence-driven radiomics for predicting primary TKI resistance in GIST patients. Sixteen patients were classifie...

Noninvasive classification of physiological and pathological high frequency oscillations in children

High frequency oscillations have been extensively investigated as interictal biomarkers of epilepsy. Yet, their value is largely debated due to the presence of physiological oscillations, which complicate distinguishing between normal versus abnormal events. So far, this debate has been addressed using intracranial EEG data from patients with drug-resistant epilepsy. Yet, this approach suffers from inability to record control data from healthy subjects and lack of whole brain coverage. Here, ...

Lacosamide modulates alpha-band network hubness: a quantitative EEG study in drug-Naïve focal epilepsy

Objective: This study investigates pharmaco-EEG changes induced by Lacosamide (LCM) in drug-naive people with focal epilepsy (PwE) and explores the association between quantitative EEG (qEEG) and long-term clinical outcome. Methods: We retrospectively identified 28 PwE and 25 healthy controls (HC). PwE were classified as seizure-free (SF) or non-seizure-free (NSF) after two years of LCM. EEGs were acquired before and ∼ 6 months after LCM. Power spectral density (PSD), amplitude-envelope corre...

3D environment with BMP-2-releasing nanocarriers enhances osteogenic commitment of human tendon stem cells