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SPATIAL VARIATION IN THE FAUNA ASSOCIATED WITH MYTILUS EDULIS ON A WAVE-EXPOSED ROCKY SHORE

The fauna associated with Mytilus edulis at a rocky wave-exposed locality in North Wales is reported. A total of fifty-nine taxa with representatives from most of the main invertebrate phyla was recorded. In terms of species richness the community was dominated by crustaceans (25 taxa), molluscs (10 taxa) and chelicerate arthropods (9 taxa), mainly mites. Fora-miniferans and crustaceans were the most abundant taxa, representing 25% and 23% of the total associated fauna respectively. Nemertean...

Urinary polyomavirus infections in neurodevelopmental disorders

We have recently reported enhanced frequencies of polyomavirus infection in post-mortem brain tissue of autistic patients compared to controls. To further explore potential contributions to neurodevelopmental disorders by polyomaviruses, we have employed specie-specific TaqMan assays to assess the prevalence and titres of BKV, JCV and SV40 inthe urines of 87 patients with autism spectrum disorder, 84 controls matched by sex and age with the autistic sample, 15 subjects with Down syndrome and ...

Age-Dependent Decrease and Alternative Splicing of Methionine Synthase mRNA in Human Cerebral Cortex and an Accelerated Decrease in Autism

The folate and vitamin B12-dependent enzyme methionine synthase (MS) is highly sensitive to cellular oxidative status, and lower MS activity increases production of the antioxidant glutathione, while simultaneously decreasing more than 200 methylation reactions, broadly affecting metabolic activity. MS mRNA levels in postmortem human cortex from subjects across the lifespan were measured and a dramatic progressive biphasic decrease of more than 400-fold from 28 weeks of gestation to 84 years ...

Deleterious coding variation associated with autism is shared across ancestries

The past decade has seen remarkable progress in identifying genes that, when impacted by deleterious coding variation, confer high likelihood for autism spectrum disorder (ASD), intellectual disability and other associated developmental disorders. However, most underlying gene discovery efforts have focused on individuals of European ancestry, limiting insights into genetic liability across diverse populations. To help address this, the Genomics of Autism in Latin American Ancestries (GALA) C...

Family history enrichment in Non-Small cell Lung Cancer: A cross-sectional − prospective study to inform referral for germline testing

Background: Family history of cancer (FHC) is a recognized proxy of inherited cancer susceptibility. In NSCLC, however, the clinical relevance of FHC remains poorly defined, and standardized approaches to identify patients enriched for pathogenic germline variants (PGVs) are lacking. Methods: FAHIC-Lung (NCT06196424) is a multicenter, cross-sectional/prospective observational study conducted in Italy. Consecutive patients with NSCLC were enrolled, detailed FHC data were collected using a dedi...

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