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Biomechanics in end-stage knee osteoarthritis: Dynamic measures provide deeper insight than radiographic alignment during functional tasks

Static radiographic alignment fails to capture the dynamic nature of joint behaviour during functional tasks. To address this, our study evaluated the relationship between Hip-Knee-Ankle angle (HKAA) and dynamic biomechanical variables (dynamic HKAA (dHKAA), via projection of hip, knee, and ankle joint centers onto the frontal plane, knee adduction moment (KAM), and knee abduction angle (KAA)), during gait and sit-to-stand tasks with and without arm assistance. A further objective was to exam...

Whole-Body Electromyostimulation Coupled with Aerobic Exercise Boosts Serum Irisin Levels in Healthy Individuals: A Pilot Study

: Background: Irisin, a myokine secreted during physical activity, has garnered attention for its potential roles in cartilage homeostasis and musculoskeletal health. Whole-body electromyostimulation (WB-EMS) is an emerging exercise modality that enhances muscle recruitment and may stimulate greater irisin release. This study aimed to compare the acute serum irisin response following aerobic exercise with and without WB-EMS in healthy individuals. Methods: A total of 24 healthy adults were en...

Wharton's Jelly Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Intervertebral Disc Degeneration Under Inflammatory Stress in an In Vitro 3D Culture System

Background Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) are emerging as a promising cell-free strategy for intervertebral disc degeneration (IDD) treatment. This study aimed to evaluate the anabolic effect of Wharton's Jelly MSC (WJ-MSC)-derived EVs on degenerative human nucleus pulposus cells (hNPCs) under in vitro inflammation using a 3D culture model.Methods Following isolation, hNPCs (n = 10) were encapsulated in alginate beads and treated with 10, 50, and 10...

Kinematic alignment preserves the mid-flexion trochlear line orientation in total knee arthroplasty: A prospective analysis from the FP-UCBM Knee Study Group

Purpose: Kinematic alignment (KA) in total knee arthroplasty (TKA) aims to restore the patient's native joint anatomy by resurfacing the distal and posterior femoral condyles. However, the trochlear anatomy is often overlooked, raising concerns about potential relative internal rotation of the femoral component. The aim of this study was to define the ?mid-flexion trochlear line’ (MTL) and assess its orientation relative to the posterior condylar line, hypothesising a parallelism between the ...

Timing and neurological recovery in metastatic spinal cord compression: short and long-term outcomes of the internal bracing technique

Purpose: Spinal metastases, affecting up to 40% of cancer patients, often arise from lung, prostate, and breast cancers. Metastatic spinal cord compression (MSCC) causes pain and neurological deficits, requiring timely surgical or radiotherapy interventions. This study evaluates neurological recovery after decompressive surgery and fixation using the “internal bracing” technique in patients with acute MSCC-related deficits, examining overall survival (OS) and its correlation with neurological...

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