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Advances in Bruton tyrosine kinase (Btk) inhibition are steered by Bruton tyrosine kinase phylogeny

Bruton tyrosine kinase (Btk) has long been known to play a key role in chronic lymphatic leukaemia, Waldenström macroglobulinaemia and other B-cell proliferative disorders. An impressive programme of drug discovery and clinical development led to the approval of covalent and non-covalent Btk inhibitors that became pillars of treatment of such malignancies. However, both a risk of cardiovascular events and the emergence of an elusive mutational landscape seem to complicate the clinical use of ...

Biochemical Sensors for Personalized Therapy in Parkinson’s Disease: Where We Stand

Since its first introduction, levodopa has remained the cornerstone treatment for Parkinson’s disease. However, as the disease advances, the therapeutic window for levodopa narrows, leading to motor complications like fluctuations and dyskinesias. Clinicians face challenges in optimizing daily therapeutic regimens, particularly in advanced stages, due to the lack of quantitative biomarkers for continuous motor monitoring. Biochemical sensing of levodopa offers a promising approach for real-ti...

Intelligent Electrochemical Sensing: A New Frontier in On-the-Fly Coffee Quality Assessment

Quality control is mandatory in the food industry and chemical sensors play a crucial role in this field. Coffee is one of the most consumed and commercialized food products globally, and its quality is of the utmost importance. Many scientific papers have analyzed coffee quality using different approaches, such as analytical and sensor analyses, which, despite their good performance, are limited to structured lab implementation. This study aims to evaluate the capability of a smart electroch...

CSR engagement and financial performance: The case of Italian unrated ESG small caps

A relevant issue in the corporate sustainability body of literature is how ESG-related information, embedded in a company's disclosure may influence the stock value in the absence of a third parties ESG score rating. This study examines the financial market's sensitivity to corporate social responsibility (CSR)-related information disclosed through public announcements and reports on responsible business conduct by listed Italian small and medium enterprises (SMEs), unrated in environmental, ...

Innovative Methodologies for the Early Detection of Breast Cancer: A Review Categorized by Target Biological Samples

Innovative biosensor technologies are revolutionizing cancer detection by offering non-invasive, sensitive, and rapid diagnostic tools, addressing the limitations of conventional screening. Non-invasive samples like breath, saliva, urine, and sweat, analyzed using advanced technologies like electronic nose systems and AI, show promise for early detection and frequent monitoring, though validation is needed. AI integration enhances data analysis and personalization. While blood-based methods r...

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