Multi-stage direct synthesis of dimethyl ether: Integrated thermodynamic, economic and environmental assessment for process intensification

Beyond The Genome: Integrative Multi-omic Analysis Of Complex Traits Using Biobank Data

Human complex traits arise from the intricate interplay between genetic, molecu- lar, and environmental influences. This thesis leverages large-scale biobank data to move beyond the genome, integrating genomic, transcriptomic, proteomic, and phenotypic layers to dissect the biological mechanisms underlying complex traits and to enhance biomarker discovery. In the first study, we investigated the molecular basis of the genetic correlation between body mass index (BMI) and brain morpholog...

“NUTRISTROKE”: THE ROLE OF NUTRITION AND BODY COMPOSITION IN POST-STROKE RECOVERY

Stroke represents one of the most pressing global health challenges, ranking as the second leading cause of death and the third leading cause of death and disability combined. Rehabilitation is a multidisciplinary process of care aimed at managing and reducing stroke-related impairments and optimizing functional recovery. Notably, even among patients with comparable baseline motor and cognitive function, some achieve worse outcome than others. This suggests that factors beyond initial neurolo...

Strategies for Paediatric Overweight and Obesity: From Nutritional Education to Clinical Management.

Childhood obesity is a chronic and multifactorial condition resulting from the complex interaction among genetic and environmental factors, family dynamics, lifestyle habits, and socioeconomic determinants. Its steadily increasing prevalence from the earliest stages of life calls for prevention and intervention strategies capable of targeting both eating behaviors and the psycho-physical factors that shape growth. Over the course of this PhD thesis, three projects were developed to counteract...