This review deals with the relationship between the immune system and the hypothalamus pituitary secretory axis and how the two are reciprocally influenced. Three main aspects are discussed: a) the action exerted by peptides of pituitary origin on the immune system; b) the production of peptides, in particular proopiomelanocortin by peripheral blood mononucler cells; c) the effect played by different cytokines on the hypothalamus pituitary axis. The message which emerge from these studies is that the neuroendocrine and the immune systems communicate utilising the same mediators; thus, each modification of the omeostasis of the endocrine system induces production of hormonal mediators addressed to the immune system, the latter signalling the neuroendocrine system via cytokines by means of information drived from non-cognitive stimuli.
HUMAN-LYMPHOCYTES AND THE HYPOTHALAMUS PITUITARY SECRETORY AXIS AS SEEN BY AN ENDOCRINOLOGIC POINT-OF-VIEW
POZZILLI P;
1991-01-01
Abstract
This review deals with the relationship between the immune system and the hypothalamus pituitary secretory axis and how the two are reciprocally influenced. Three main aspects are discussed: a) the action exerted by peptides of pituitary origin on the immune system; b) the production of peptides, in particular proopiomelanocortin by peripheral blood mononucler cells; c) the effect played by different cytokines on the hypothalamus pituitary axis. The message which emerge from these studies is that the neuroendocrine and the immune systems communicate utilising the same mediators; thus, each modification of the omeostasis of the endocrine system induces production of hormonal mediators addressed to the immune system, the latter signalling the neuroendocrine system via cytokines by means of information drived from non-cognitive stimuli.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
