SUMMARY. To determine the single or combined effect ofboth rs12979860 and rs8099917 SNPs on HCV treatmentresponse, these variants were genotyped in samples from acohort of 170 patients infected with different HCV genotypes (HCVGT). The favourable rs12979860 CC genotype was found only in patients with sustained or rapid virological responses (SVR/RVR) and at significantly high proportionsin HCVGT1/4 SVR patients. A significant association wasalso found between the rs8099917 TT genotype and SVR in both HCVGT1/4 and HCVGT2/3 groups of patients. Incontrast, we found that there was significantly more of thers8099917 GG genotype in nonresponders (NR) than in SVRpatients which suggests a good association of the minorhomozygote GG with the lack of treatment response. Thecombination of rs12979860/rs8099917 CC/TT favourable genotypes was found only in SVR patients and matched the frequency observed for their rs12979860 CC genotypes alone. By contrast, the inverse unfavourable correlaters12979860/rs8099917 TT/GG genotype was seen more inNR than in SVR patients as observed for the single GGgenotype. This study confirms the impact of both rs12979860 and/or rs8099917 IL-28B SNPs on treatmentinduced clearance of HCV-RNA and demonstrates that the rs12979860 CC genotype is stronger than rs8099917 TT genotype in predicting a positive treatment response inHCVGT1/4 patients. The unfavourable rs8099917 GGgenotype seems to be more important in predicting the failure of treatment response independently from HCV genotype.
Interleukin-28B (IL-28B) single-nucleotide polymorphisms and interferon plus ribavirin treatment outcome in Italian chronically HCV-infected patients
Riva E;Picardi A;Vincenzi B;
2012-01-01
Abstract
SUMMARY. To determine the single or combined effect ofboth rs12979860 and rs8099917 SNPs on HCV treatmentresponse, these variants were genotyped in samples from acohort of 170 patients infected with different HCV genotypes (HCVGT). The favourable rs12979860 CC genotype was found only in patients with sustained or rapid virological responses (SVR/RVR) and at significantly high proportionsin HCVGT1/4 SVR patients. A significant association wasalso found between the rs8099917 TT genotype and SVR in both HCVGT1/4 and HCVGT2/3 groups of patients. Incontrast, we found that there was significantly more of thers8099917 GG genotype in nonresponders (NR) than in SVRpatients which suggests a good association of the minorhomozygote GG with the lack of treatment response. Thecombination of rs12979860/rs8099917 CC/TT favourable genotypes was found only in SVR patients and matched the frequency observed for their rs12979860 CC genotypes alone. By contrast, the inverse unfavourable correlaters12979860/rs8099917 TT/GG genotype was seen more inNR than in SVR patients as observed for the single GGgenotype. This study confirms the impact of both rs12979860 and/or rs8099917 IL-28B SNPs on treatmentinduced clearance of HCV-RNA and demonstrates that the rs12979860 CC genotype is stronger than rs8099917 TT genotype in predicting a positive treatment response inHCVGT1/4 patients. The unfavourable rs8099917 GGgenotype seems to be more important in predicting the failure of treatment response independently from HCV genotype.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
