Immediate and long-term outcomes of ischemic versus non-ischemic functional mitral regurgitation in patients treated with MitraClip: insights from the 2011-12 Pilot European Sentinel Registry of Percutaneous Edge-to-Edge Mitral Valve Repair

BACKGROUND Outcome data comparing ischemic functional mitralregurgitation (I-FMR) versus non-ischemic FMR (NI-FMR) followingpercutaneous repair are not currently available in the literature. Weaimed to describe the early and 12-month results following MitraClipdevice implantation regarding the two etiologies.METHODS Between January 2011 December 2012 the Transcatheter ValveTreatment Sentinel Pilot Registry included 452 patients with FMR whounderwent MitraClip procedure in 25 centers of 8 European countries.RESULTS The prevalent etiology was I-FMR (235 patients, 52.0%). I-FMRgroup had a significant higher proportion of men (74.9 vs 59.9%, p<0.001)and surgical risk (logistic EuroScore 24.818.2 vs 18.816.3, p<0.001).Acute procedural success was high (95.8%) and similar between groups(p¼0.48). Patients with I-FMR required a higher, albeit not significant,number of clips to reduce MR (p¼0.08). In-hospital mortality was low(2.0%) without significant differences between etiologies. Both I-FMR andNI-FMR showed a significant post-clip improvement in NYHA functionalclass with the majority of patients exhibiting a NYHA class