Background/Aims: Growth hormone (GH) -resistance complicates liver cirrhosis, with low levels of insulin-like growth factor-l (IGF-1), IGF binding protein-3, and acid labile subunit (ALS) despite high serum GH concentrations. A GH-test has been already proposed to define liver functionand prognosis. We aimed to compare liver response to short term GH challenge among patients with liver cirrhosis and with non-cirrhotic chronic liver disease (CLD).Methods: 17 patients with chronic hepatitis (CH), and 19 patients with cirrhosis(CIR) were studied and compared with 11 controls (CON). Patients received 0.14 UVKg of GH SC, and blood was drawn before and 24 hoursafter GH injection to determine IGF-1 and ALS levels. Results: Basal IGF-1 resulted significantly lower in CIR respect to CH(.5.3&5.8 vs 14.9&10.5 nmol/l, p
Growth hormone-stimulated insulin-like factor-1 and acid labile subunit in chronic liver disease
Picardi A;Vespasiani Gentilucci U;Zardi EM;Manfrini S;Afeltra A;Pozzilli P
2003-01-01
Abstract
Background/Aims: Growth hormone (GH) -resistance complicates liver cirrhosis, with low levels of insulin-like growth factor-l (IGF-1), IGF binding protein-3, and acid labile subunit (ALS) despite high serum GH concentrations. A GH-test has been already proposed to define liver functionand prognosis. We aimed to compare liver response to short term GH challenge among patients with liver cirrhosis and with non-cirrhotic chronic liver disease (CLD).Methods: 17 patients with chronic hepatitis (CH), and 19 patients with cirrhosis(CIR) were studied and compared with 11 controls (CON). Patients received 0.14 UVKg of GH SC, and blood was drawn before and 24 hoursafter GH injection to determine IGF-1 and ALS levels. Results: Basal IGF-1 resulted significantly lower in CIR respect to CH(.5.3&5.8 vs 14.9&10.5 nmol/l, pI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
