Females with slow transit constipation (STC) exhibit progesterone receptor (P4R) overexpression in colon muscle that impair their contractility. These studies examined whether these patients have an overexpression of P4R in epithelial cells and whether P4 affects the SERT-5-HT pathway.

Progesterone receptors and serotonin levels in colon epithelial cells from females with slow transit constipation

GUARINO M.;CICALA M;RIPETTI V;
2011-01-01

Abstract

Females with slow transit constipation (STC) exhibit progesterone receptor (P4R) overexpression in colon muscle that impair their contractility. These studies examined whether these patients have an overexpression of P4R in epithelial cells and whether P4 affects the SERT-5-HT pathway.
Adolescent; Adult; Animals; Cells, Cultured; Colon; Constipation; Epithelial Cells; Female; Humans; Male; Mice; Mice, Knockout; Middle Aged; Progesterone; Receptors, Progesterone; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tryptophan Hydroxylase; Young Adult
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/2183
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