Thermal effects affecting spatiotemporal behavior of cardiac tissue are discussed by relating temperaturevariations to proarrhythmic dynamics in the heart. By introducing a thermoelectric coupling in a minimalmodel of cardiac tissue, we are able to reproduce experimentally measured dynamics obtained simultaneouslyfrom epicardial and endocardial canine right ventricles at different temperatures. A quantitative description ofemergent proarrhythmic properties of restitution, conduction velocity, and alternans regimes as a function oftemperature is presented. Complex discordant alternans patterns that enhance tissue dispersion consisting of onewave front and three wave backs are described in both simulations and experiments. Possible implications formodel generalization are finally discussed.

Role of temperature on nonlinear cardiac dynamics

Gizzi A;Cherubini C;
2013-01-01

Abstract

Thermal effects affecting spatiotemporal behavior of cardiac tissue are discussed by relating temperaturevariations to proarrhythmic dynamics in the heart. By introducing a thermoelectric coupling in a minimalmodel of cardiac tissue, we are able to reproduce experimentally measured dynamics obtained simultaneouslyfrom epicardial and endocardial canine right ventricles at different temperatures. A quantitative description ofemergent proarrhythmic properties of restitution, conduction velocity, and alternans regimes as a function oftemperature is presented. Complex discordant alternans patterns that enhance tissue dispersion consisting of onewave front and three wave backs are described in both simulations and experiments. Possible implications formodel generalization are finally discussed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/2770
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