Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Martin, M; Holmes, Fa; Ejlertsen, B; Delaloge, S; Moy, B; Iwata, H; von Minckwitz, G; Skl, Chia; Mansi, J; Barrios, Ch; Gnant, M; Tomašević, Z; Denduluri, N; Šeparović, R; Gokmen, E; Bashford, A; Ruiz Borrego, M; Kim, Sb; Jakobsen, Eh; Ciceniene, A; Inoue, K; Overkamp, F; Heijns, Jb; Armstrong, Ac; Link, Js; Joy, Aa; Bryce, R; Wong, A; Moran, S; Yao, B; F, Xu; Auerbach, A; Buyse, M; Chan, A; Harvey, V; Tomek, R; Robert, Nj; Gore I, Jr.; Smith JW 2nd,; Masuda, N; Di Sean Kendall, S; Harker, Wg; Petrakova, K; Guerrero Zotano, A; Simon, Ar; Konstantinovic, Zn; Iannotti, No; Tassone, P; Rodriguez, Gi; Jáñez Martinez, N; Crespo Massieu, C; Smickoska, S; Somali, I; Yilmaz, U; Alonso, Mg; Rosales, Am; Cold, S; Knoop, As; Patt, D; Hellerstedt, Ba; Morales Murillo, S; Mayer, Ia; Means-Powell, Ja; Hui, R; Senecal, Fm; De Boer RH,; Shen, Z; Luczak, Aa; Jwy, Chui; Tsang, Jw; Lang, I; Rai, Y; Hozumi, Y; Ten Tije AJ,; Bhandari, M; Crc, Osborne; Ohtani, S; Higaki, K; Watanabe, K; Taguchi, K; Takahashi, M; 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Ruxer, R; Wilks, St; Kotasek, D; Popov, V; Taskova, V; Marinova-Venkova, V; Timcheva, C; Desbiens, C; Ayoub, Jp; Grenier, D; Marschner, N; Tesch, H; Lueck, Hj; Janssen, J; Schwaner, I; Wahlstrom, S; Brix, Eh; Vallentin, S; Kristensen, D; Andreeva, A; Glavicic, V; Calvo Plaza, I; Anton Torres, A; Veyret, C; Bergerat, Jp; Bourbouloux, E; Ella, Wa; Algurafi, H; Robinson, A; Kim, Sj; Taguchi, T; Juozaityte, E; Madretsma, S; Radema, S; Czerniawska-Meier, M; Rogowski, W; Wagnerova, M; Richards, Da; Tan-Chiu, E; Vasileios, A; Henderson, Ca; Holden, Vr; Wang, X; Tong, Z; Yang, J; Gonzalez, Me; Rezai, M; Hackmann, J; de Dueñas EM,; de Las Heras BB,; Dourthe, Lm; Chocteau-Bouju, D; Bougnoux, P; Kakolyris, S; Kalofonos, H; Pectasidis, D; Ty, Ng; Pajkos, G; Somogyine, Ee; Tonini, G; Giuffrida, D; Takao, S; Ishitobi, M; Inaji, H; Tokuda, Y; Wozniak, K; Lungulescu, D; Ys, Lu; Chang, Kj; Hill, J; Croot, Cc; Dekker, A; Belman, Nd; Conde, M; Michaelson, Ra; Kemmer, K; Chui, S; Luoh, Sw; Nahum, K; Greenspan, Ar; Nichols, Jc; Encarnacion, Ca; Tmj, Niederman; Lee, T; Alexander, R; Gordon, R; Tomova, A; Rauch, D; Popescu, Ra; Rojas, Ga; Vanasek, J; Neunhoeffer, T; Barinoff, J; Graffunder, G; Wolfgang, A; Bojko, P; Heinrich, B; von der Assen, A; Antonovic, Bj; Adrian, L; Ramos Vazquez, M; Gonzalez Santiago, S; Dieras, V; Bishop, Jm; Perren, Tj; Varthalitis, I; Mavroudis, D; Georgoulias, V; Lwc, Chow; Cct, Yau; Liang, Rh; Pikó, B; Wéber, A; Kaufman, B; Drumea, K; Nuzzo, F; De Matteis, A; Nuzzo, F; Carteni, G; Tokunaga, E; Ishida, M; Ohno, S; Sato, N; Kuroi, K; Nishimura, R; Watanabe, J; Choi, Yj; Park, Kh; Wojtukiewicz, M; Jassem, J; Loman, N; Askoy, S; Altundag, Mk; Saip, P; Ali, Ma; Wade JL 3rd,; Chien, Aj; Brandt, D; Novik, Y; Jani, C; Rice, Rl; Yar, Gaffar; Keaton, Mr; Bajaj, R; Kimmick, G; Campbell, D; De Boer RH,; Turnquest, T; Lucas, S; Dube, P; B, Xu; Schilling, J; Apel, K; Sorensen, Pg; Vestlev, Pm; Jensen, Bb; Haahr, V; Lescure, Ar; Grana Suarez, B; Saura Manich, C; Jacquin, Jp; Samreen, A; Boiangiu, I; Dank, M; Falci, C; Jirillo, A; Cinieri, S; Ueno, T; Sato, F; Yamashiro, H; Sugie, T; Lee, Ks; Js, Ro; Park, Ih; Bustam, Az; Suszko-Kazarnowicz, M; Piktel, A; Krzemieniecki, K; Iorga, Pg; Yap, Ys; Kakalejcik, M; Sevinc, A; Ozguroglu, M; Chen, Sc; Greenberg, Rh; Eisemann, Ad; Droder, R; Abbasi, Mr; Vaysburd, M; Caldera, Hj; Haley, Bb; Robin, E; Inhorn, Rc; Hufnagel, D; Kenyon, Pd; Spremulli, E; Silverman, P; Jain, S; Weigand, R; Mebis, J; Koynova, T; Lesperance, B; Prausova, J; Kohne, Ch; Schneeweiss, A; Jackisch, C; Fuxius, S; Cubedo Cervera, R; Urruticoechea Ribate, A; Pernas Simon, S; Valero Gallego, J; Arcusa Lanza, A; Del Pilar Alvarez, M; Florian Gerico, J; Cany, L; Stebbing, J; Labudovic, D; Gugic, D; Vrbanec, D; Roila, F; Barni, S; Bidoli, P; Mukai, H; Bermudez, V; Eniu, A; Mirtsching, Bc; Ibrahim, E; Trey, J; Hergenroeder, Pf; Mahmood, A; Gonzalez, A; Kaplan, Eh; Ban, S; Patel, D; Clowney, B; Hoelzer, K; Schwartz, Gh; Salkeni, M; Abraham, J; Narula, S; Jabboury, K; 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Ruggeri, Em; Gamucci, T; Van Groeningen CJ,; Banas, R; Loman, N; Alkis, N; Hou, Mf; Krie, Ak; Vrindavanam, Ns; Howard, Om; Citrin, D; Morginstin, Ms; Desai, A; Sanchez, Ij; Nixon DA, Jr.; Beatty, Pg; Edmiston, K; Mclaughlin, M; Eneman, Jd; Lynch, Ca; O'Brien, E; Call, Ja; Lanier, Ks; Conlin, A; Brooks, Dj; Mcintyre, K; Saltzman, Ma; Castine MJ 3rd,; Ortega, Gl; Choi, Ym; Reynolds, Ch; Brescia, Fa; Kramer, R; Kohn, Ad; Micha, Jp; Rhee, Jm; Shah, S; Riseberg, Da; Patterson, Wk; Salmon, Jp; Andre, C; Bols, A; D'Hondt, R; Luce, S; Nouwynck, C; Pelgrims, G; Richard, V; Verschuere, J; Geldhof, K; Caspar, C; Luo, R; Bednarik, O; Schwedler, K; Schmidt, M; Neumeister, R; Bischoff, J; Rack, B; Repp, R; Fries, S; Adrion, R; Schulz, V; Klare, P; Danei, M; Ossenbuhl, D; Kusche, Jm; Griesinger, F; Baena Canada JM,; Martinez Del Prado, P; Machover, D; Mayeur, D; Trufflandier, N; Delecroix, V; Mousseau, M; Mouret-Reynier, Ma; Nabholtz, Jm; Chetiyawardana, Ad; Papandreou, C; Hornyak, L; Faluhelyi, Z; Simo, E; Di Palma, M; Cognetti, F; Gorzegno, G; Dogliotti, L; Gridelli, C; Falcone, A; Soto Parra, H; Buscarino, C; Sa, Im; Sanchez Llamas, B; Dercksen, W; Erdkamp, F; Ruit, Jb; Braun, H; Jea, Portielje; Ciltas, A; Buyukberber, S; Benekli, M; Zahalsky, Aj; Jaslow, R; Thomas, Gw; Maini, A; Wiznitzer, I; Khojasteh, A; Francisco Gonzalez, M; Kong, Lr; Padmanabhan, A; Conkright, Wa; Swain, Sm; Faig, De; Jain, K; Yanagihara, Rh; Ottaviano, Y; Delmas, A; Steele, Ha; Rainey, Gk; Harris, Pj; Burris, Jk; Rupard, Ej; Tan, E; Whitworth, Pw; Bova, Ar; Anderson, Ic; Shirinian, M; Tin-U, C; O'Rourke, Tj; Roberts, Ms; Francisco, M; Pierson, As; Byeff, Pd; Kovach, Pa; Caton JR, Jr.; Rarick, Mu; Schimidt WG, Jr.; Stopeck, At; Swart, R; Carrillo Flores MR,; Alemany, Ca; Lozada, B; Weinstein, Pl; Wang, W; Porubcin, M; Ellison, Dm; Geils, Gf; Rivera, E; Charif, M.

doi:10.1016/S1470-2045(17)30717-9.

Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

Martin M;Holmes FA;Ejlertsen B;Delaloge S;Moy B;Iwata H;von Minckwitz G;Chia SKL;Mansi J;Barrios CH;Gnant M;Tomašević Z;Denduluri N;Šeparović R;Gokmen E;Bashford A;Ruiz Borrego M;Kim SB;Jakobsen EH;Ciceniene A;Inoue K;Overkamp F;Heijns JB;Armstrong AC;Link JS;Joy AA;Bryce R;Wong A;Moran S;Yao B;Xu F;Auerbach A;Buyse M;Chan A;Harvey V;Tomek R;Robert NJ;Gore I Jr.;Smith JW 2nd;Masuda N;Di Sean Kendall S;Harker WG;Petrakova K;Guerrero Zotano A;Simon AR;Konstantinovic ZN;Iannotti NO;Tassone P;Rodriguez GI;Jáñez Martinez N;Crespo Massieu C;Smickoska S;Somali I;Yilmaz U;Alonso MG;Rosales AM;Cold S;Knoop AS;Patt D;Hellerstedt BA;Morales Murillo S;Mayer IA;Means-Powell JA;Hui R;Senecal FM;De Boer RH;Shen Z;Luczak AA;Chui JWY;Tsang JW;Lang I;Rai Y;Hozumi Y;Ten Tije AJ;Bhandari M;Osborne CRC;Ohtani S;Higaki K;Watanabe K;Taguchi K;Takahashi M;Filipovic S;Hansen VL;Rao VP;Gupta M;Petrov P;Coudert B;Vojnovic Z;Polya Z;Miyaki T;Yamamoto N;Brincat S;Lesniewski-Kmak K;Chmielowska E;Birhiray RE;Citron ML;Papish SW;Berry WR;Langkjer ST;Garcia Sáenz JA;Arance AM;Efrat N;Sarosiek T;Grzeda L;Manalo Y;Smith JC;Vaziri I;Healey T;Rahim Y;Luk C;Dingle B;Franco S;Sorensen PG;Anand A;Khan S;Fountzilas G;Aogi K;Shimizu S;Mikulova M;Spanik S;Somer RA;Flynn PJ;Coward J;Mainwaring P;Jerusalem G;Segura-Ojezzar C;Levy C;Delozier T;Khayat D;Coleman RE;Rolles MJ;Maisano R;Nardi M;Ito Y;Yumuk PF;Basaran G;Serdar Turhal N;Wilkinson MJ;Green NB;Sidrys AP;Hallmeyer S;Testori DJ;Sridhar S;Chang J;Sun Q;Jara-Sanchez C;Rubio X;Garrido ML;De La Haba Rodriguez JR;Perello Martorell A;Avelia Mestre A;Rifa Ferrer J;Del Barco Berron S;Nagy Z;Tanaka M;Im YH;Carroll RR;Dickerson LC;Mace JR;Rivera R;Klein LM;Ruxer R;Wilks ST;Kotasek D;Popov V;Taskova V;Marinova-Venkova V;Timcheva C;Desbiens C;Ayoub JP;Grenier D;Marschner N;Tesch H;Lueck HJ;Janssen J;Schwaner I;Wahlstrom S;Brix EH;Vallentin S;Kristensen D;Andreeva A;Glavicic V;Calvo Plaza I;Anton Torres A;Veyret C;Bergerat JP;Bourbouloux E;Ella WA;Algurafi H;Robinson A;Kim SJ;Taguchi T;Juozaityte E;Madretsma S;Radema S;Czerniawska-Meier M;Rogowski W;Wagnerova M;Richards DA;Tan-Chiu E;Vasileios A;Henderson CA;Holden VR;Wang X;Tong Z;Yang J;Gonzalez ME;Rezai M;Hackmann J;de Dueñas EM;de Las Heras BB;Dourthe LM;Chocteau-Bouju D;Bougnoux P;Kakolyris S;Kalofonos H;Pectasidis D;Ng TY;Pajkos G;Somogyine EE;Tonini G;Giuffrida D;Takao S;Ishitobi M;Inaji H;Tokuda Y;Wozniak K;Lungulescu D;Lu YS;Chang KJ;Hill J;Croot CC;Dekker A;Belman ND;Conde M;Michaelson RA;Kemmer K;Chui S;Luoh SW;Nahum K;Greenspan AR;Nichols JC;Encarnacion CA;Niederman TMJ;Lee T;Alexander R;Gordon R;Tomova A;Rauch D;Popescu RA;Rojas GA;Vanasek J;Neunhoeffer T;Barinoff J;Graffunder G;Wolfgang A;Bojko P;Heinrich B;von der Assen A;Antonovic BJ;Adrian L;Ramos Vazquez M;Gonzalez Santiago S;Dieras V;Bishop JM;Perren TJ;Varthalitis I;Mavroudis D;Georgoulias V;Chow LWC;Yau CCT;Liang RH;Pikó B;Wéber A;Kaufman B;Drumea K;Nuzzo F;De Matteis A;Nuzzo F;Carteni G;Tokunaga E;Ishida M;Ohno S;Sato N;Kuroi K;Nishimura R;Watanabe J;Choi YJ;Park KH;Wojtukiewicz M;Jassem J;Loman N;Askoy S;Altundag MK;Saip P;Ali MA;Wade JL 3rd;Chien AJ;Brandt D;Novik Y;Jani C;Rice RL;Gaffar YAR;Keaton MR;Bajaj R;Kimmick G;Campbell D;De Boer RH;Turnquest T;Lucas S;Dube P;Xu B;Schilling J;Apel K;Sorensen PG;Vestlev PM;Jensen BB;Haahr V;Lescure AR;Grana Suarez B;Saura Manich C;Jacquin JP;Samreen A;Boiangiu I;Dank M;Falci C;Jirillo A;Cinieri S;Ueno T;Sato F;Yamashiro H;Sugie T;Lee KS;Ro JS;Park IH;Bustam AZ;Suszko-Kazarnowicz M;Piktel A;Krzemieniecki K;Iorga PG;Yap YS;Kakalejcik M;Sevinc A;Ozguroglu M;Chen SC;Greenberg RH;Eisemann AD;Droder R;Abbasi MR;Vaysburd M;Caldera HJ;Haley BB;Robin E;Inhorn RC;Hufnagel D;Kenyon PD;Spremulli E;Silverman P;Jain S;Weigand R;Mebis J;Koynova T;Lesperance B;Prausova J;Kohne CH;Schneeweiss A;Jackisch C;Fuxius S;Cubedo Cervera R;Urruticoechea Ribate A;Pernas Simon S;Valero Gallego J;Arcusa Lanza A;Del Pilar Alvarez M;Florian Gerico J;Cany L;Stebbing J;Labudovic D;Gugic D;Vrbanec D;Roila F;Barni S;Bidoli P;Mukai H;Bermudez V;Eniu A;Mirtsching BC;Ibrahim E;Trey J;Hergenroeder PF;Mahmood A;Gonzalez A;Kaplan EH;Ban S;Patel D;Clowney B;Hoelzer K;Schwartz GH;Salkeni M;Abraham J;Narula S;Jabboury K;Mocharnuk RS;McDonough RH;Sikes DH;Kawanchi RH;Schlabach L;McCachren SS Jr.;Cosgriff TM;Dreisbach L;DeMichele A;Pawl L;Lucas J;Shinn LC;Alkhouri N;Monga M;Lindquist DL;Anderson TC;Khurshid H;Witherby S;Erickson N;Traynor A;Bose R;Pluard TJ;Jones MC;Prakash S;Volterra F;Capo G;Flaherty LE;Gartner E;Baidas S;Okazaki I;Nguyen B;Rakowski T;Oliff I;Leach JW;Anderson D;Kubiak K;Tsai M;Vroman P;Deleu I;Lybaert W;Borms M;Couture F;Wilson JJ;Hunt G;Holland DR;Mingrone W;Wang S;Liu D;Jiang Z;Benesova V;Smakal M;Garnolova P;Vesper AS;Neumann M;Janni W;Liedtke C;Fischer D;Grischke EM;Seeger D;Moebus V;Prechtl A;Carlos Camara Toral J;Sanchez Munoz A;Gonzalez Jimenez S;Cassinello Espinosa J;Cirauqui B;Margeli Vila M;Batista Lopez N;Chacon Lopez-Muniz JI;de la Cruz Mora MA;Mailliez A;Vanlemmens L;Pouessel D;Espie M;Conibear J;Roylance R;Harnett A;Geffen D;Ruggeri EM;Gamucci T;Van Groeningen CJ;Banas R;Loman N;Alkis N;Hou MF;Krie AK;Vrindavanam NS;Howard OM;Citrin D;Morginstin MS;Desai A;Sanchez IJ;Nixon DA Jr.;Beatty PG;Edmiston K;McLaughlin M;Eneman JD;Lynch CA;O'Brien E;Call JA;Lanier KS;Conlin A;Brooks DJ;McIntyre K;Saltzman MA;Castine MJ 3rd;Ortega GL;Choi YM;Reynolds CH;Brescia FA;Kramer R;Kohn AD;Micha JP;Rhee JM;Shah S;Riseberg DA;Patterson WK;Salmon JP;Andre C;Bols A;D'hondt R;Luce S;Nouwynck C;Pelgrims G;Richard V;Verschuere J;Geldhof K;Caspar C;Luo R;Bednarik O;Schwedler K;Schmidt M;Neumeister R;Bischoff J;Rack B;Repp R;Fries S;Adrion R;Schulz V;Klare P;Danei M;Ossenbuhl D;Kusche JM;Griesinger F;Baena Canada JM;Martinez Del Prado P;Machover D;Mayeur D;Trufflandier N;Delecroix V;Mousseau M;Mouret-Reynier MA;Nabholtz JM;Chetiyawardana AD;Papandreou C;Hornyak L;Faluhelyi Z;Simo E;Di Palma M;Cognetti F;Gorzegno G;Dogliotti L;Gridelli C;Falcone A;Soto Parra H;Buscarino C;Im SA;Sanchez Llamas B;Dercksen W;Erdkamp F;Ruit JB;Braun H;Portielje JEA;Ciltas A;Buyukberber S;Benekli M;Zahalsky AJ;Jaslow R;Thomas GW;Maini A;Wiznitzer I;Khojasteh A;Francisco Gonzalez M;Kong LR;Padmanabhan A;Conkright WA;Swain SM;Faig DE;Jain K;Yanagihara RH;Ottaviano Y;Delmas A;Steele HA;Rainey GK;Harris PJ;Burris JK;Rupard EJ;Tan E;Whitworth PW;Bova AR;Anderson IC;Shirinian M;Tin-U C;O'Rourke TJ;Roberts MS;Francisco M;Pierson AS;Byeff PD;Kovach PA;Caton JR Jr.;Rarick MU;Schimidt WG Jr.;Stopeck AT;Swart R;Carrillo Flores MR;Alemany CA;Lozada B;Weinstein PL;Wang W;Porubcin M;Ellison DM;Geils GF;Rivera E;Charif M.

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Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial.

2017-01-01

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