Evidence has lately emerged regarding an increased risk of SARS-CoV-2 with worse prognosis in patients with obesity, especially among the young. Weight excess is a well-established respiratory disease risk factor, and the newly reported correlation is therefore unsurprising. The underlying pathophysiology is likely multi-stranded, ranging from complement system hyperactivation, increased Interleukin-6 secretion, chronic inflammation, presence of comorbidities such as diabetes and hypertension, and a possible local, detrimental effect within the lung. Further understanding the link between obesity and SARS-CoV-2 is crucial, as this could aid proper tailoring of immunomodulatory treatments, together with improving stratification among those possibly requiring critical care. © 2020 John Wiley & Sons Ltd

Obesity and SARS-CoV-2: A population to safeguard

Tuccinardi D;Manfrini S;
2020-01-01

Abstract

Evidence has lately emerged regarding an increased risk of SARS-CoV-2 with worse prognosis in patients with obesity, especially among the young. Weight excess is a well-established respiratory disease risk factor, and the newly reported correlation is therefore unsurprising. The underlying pathophysiology is likely multi-stranded, ranging from complement system hyperactivation, increased Interleukin-6 secretion, chronic inflammation, presence of comorbidities such as diabetes and hypertension, and a possible local, detrimental effect within the lung. Further understanding the link between obesity and SARS-CoV-2 is crucial, as this could aid proper tailoring of immunomodulatory treatments, together with improving stratification among those possibly requiring critical care. © 2020 John Wiley & Sons Ltd
2020
adipocyte; adult respiratory distress syndrome; artificial ventilation; body weight; chronic inflammation; comorbidity; complement system; coronavirus disease 2019; cytokine release; diabetes mellitus; human; hypertension; immunomodulation; lung parenchyma; mortality; nonhuman; Note; obesity; pathogenesis; patient care; population; priority journal; prognosis; respiratory tract disease; risk factor; Severe acute respiratory syndrome coronavirus 2
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/5302
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