Hubs, diversity, and synchronization in FitzHugh-Nagumo oscillator networks: Resonance effects and biophysical implications

Using the FitzHugh-Nagumo equations to represent the oscillatory electrical behavior of β-cells, we develop a coupled oscillator network model with cubic lattice topology, showing that the emergence of pacemakers or hubs in the system can be viewed as a natural consequence of oscillator population diversity. The optimal hub to nonhub ratio is determined by the position of the diversity-induced resonance maximum for a given set of FitzHugh-Nagumo equation parameters and is predicted by the model to be in a range that is fully consistent with experimental observations. The model also suggests that hubs in a β-cell network should have the ability to "switch on"and "off"their pacemaker function. As a consequence, their relative amount in the population can vary in order to ensure an optimal oscillatory performance of the network in response to environmental changes, such as variations of an external stimulus.