Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible ‘window’ to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT‐ A) is a non‐invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT‐A in glaucoma and central nervous system conditions such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT‐A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.

Optical coherence tomography angiography in neurodegenerative disorders

Di Zazzo A.;
2020-01-01

Abstract

Retinal microcirculation shares similar features with cerebral small blood vessels. Thus, the retina may be considered an accessible ‘window’ to detect the microvascular damage occurring in the setting of neurodegenerative disorders. Optical coherence tomography angiography (OCT‐ A) is a non‐invasive imaging modality providing depth resolved images of blood flow in the retina, choroid, and optic nerve. In this review, we summarize the current literature on the application of OCT‐A in glaucoma and central nervous system conditions such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis. Future directions aiming at evaluating whether OCT‐A can be an additional biomarker for the early diagnosis and monitoring of neurodegenerative disorders are also discussed.
2020
Alzheimer’s disease
Glaucoma
Multiple sclerosis
Neurodegenerative disorders
Optical coherence tomography angiography
Parkinson’s disease
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/58797
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