Statins are a class of drugs widely used in clinical practice for their lipid-lowering and pleiotropic effects. In recent years, a correlation between statins and platelet function has been unveiled in the literature that might introduce new therapeutic indications for this class of drugs. This review is aimed at summarizing the mechanisms underlying statin-platelet interaction in the cardiologic scenario and building the basis for future in-depth studies.

Effect of Statins on Platelet Activation and Function: From Molecular Pathways to Clinical Effects

Nenna, Antonio;Lusini, Mario;Chello, Massimo
2021-01-01

Abstract

Statins are a class of drugs widely used in clinical practice for their lipid-lowering and pleiotropic effects. In recent years, a correlation between statins and platelet function has been unveiled in the literature that might introduce new therapeutic indications for this class of drugs. This review is aimed at summarizing the mechanisms underlying statin-platelet interaction in the cardiologic scenario and building the basis for future in-depth studies.
2021
Aspirin
Blood Platelets
CD36 Antigens
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipidemias
Organic Anion Transporters
Platelet Activation
Signal Transduction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/67352
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