In order to evaluate neutrophil-to-lymphocyte ratio (NLR) and derived neutrophil-to-lymphocyte ratio(d-NLR) in predicting response and complications in rectal cancer patients who underwent surgeryafter neo-adjuvant radio-chemotherapy, 87 patients were evaluated. Cutoffs before and after radiochemotherapywere respectively 2.8 and 3.8 for NLR, and 1.4 and 2.3 for d-NLR. They were analyzedin relation to clinical and pathological outcomes. Patients with preoperative NLR and d-NLR higherthan cutoffs had significantly higher rates of tumor regression grade response (TRG 4) and postoperativecomplications. Elevated NLR and d-NLR after radio-chemotherapy are associated with worsepathological and clinical outcome.

Neutrophil to lymphocyte ratio (NLR) and derived neutrophil to lymphocyte ratio (D-NLR) predict non-responders and postoperative complications in patients undergoing radical surgery after neo-adjuvant radio-chemotherapy for rectal adenocarcinoma

Caputo D;Caricato M;Fiore M;Coppola R.
2016-01-01

Abstract

In order to evaluate neutrophil-to-lymphocyte ratio (NLR) and derived neutrophil-to-lymphocyte ratio(d-NLR) in predicting response and complications in rectal cancer patients who underwent surgeryafter neo-adjuvant radio-chemotherapy, 87 patients were evaluated. Cutoffs before and after radiochemotherapywere respectively 2.8 and 3.8 for NLR, and 1.4 and 2.3 for d-NLR. They were analyzedin relation to clinical and pathological outcomes. Patients with preoperative NLR and d-NLR higherthan cutoffs had significantly higher rates of tumor regression grade response (TRG 4) and postoperativecomplications. Elevated NLR and d-NLR after radio-chemotherapy are associated with worsepathological and clinical outcome.
colorectal cancer; anal cancer; prognosis and response prediction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/6757
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