The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF).

Parasympathetic activity increases with digital microvascular damage and vascular endothelial growth factor in systemic sclerosis

Navarini, Luca;Afeltra, Antonella;
2018-01-01

Abstract

The imbalance between angiogenic and angiostatic factors with derangement of the microvasculature are hallmarks of systemic sclerosis (SSc). Raynaud's phenomenon in SSc probably is due to the impaired neuroendothelial control mechanisms between vasoconstriction and vasodilatation. The aim of this study is to evaluate autonomic nervous system function using heart rate variability (HRV) analysis and to correlate with vascular endothelial growth factor (VEGF).
Adult; Disease Progression; Female; Fingers; Heart; Heart Rate; Hemodynamics; Humans; Male; Microvessels; Middle Aged; Parasympathetic Nervous System; Raynaud Disease; Regional Blood Flow; Scleroderma, Systemic; Skin Ulcer; Vascular Endothelial Growth Factor A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/70495
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