Background: ‘Fatigue’ can persist for months or even for years after the end of treatment. Aims: Our study’s aim was to verify the presence of absence of ‘fatigue’ in women with history of breast cancer after 1–5 years from end of primary treatment and to assess the correlations between fatigue and some considered variables. Materials and Methods: Prospective observational multicentric case-control study. Inclusion criteria: history of non metastatic breast cancer; interval time from the end of treatment between 1 and 5 years, age over 18 years. Exclusion criteria: actual neoplastic disease, history of treatment for other types of tumor, any severe uncontrolled disease. Control sample: 100 women with no history of cancer or other severe uncontrolled diseases. Functional Assessment of Cancer Therapy-Fatigue (FACT-F) has been used to measure ‘Fatigue’. Results: 117 women with history of breast cancer. Median age: 60 years (37–83). 83 patients submitted to adjuvant chemo-therapy. Healthy sample: 100 women with median age of 58 years (34–78). A statistically significant difference in terms of fatigue between studied group and control group has been not observed (P = 0.652). On the contrary, a progressive and statistically significant reduction of fatigue levels has been observed in the studied group with the passing of time (P = 0.036). Besides, neither adjuvant chemo-therapy (P = 0.430) nor hormone-therapy (P = 0.296) have presented a correlation with ‘fatigue’. A correlation between age and ‘fatigue’ levels has not found (P = 0.282). Fatigue levels between women with nodal disease or without nodal disease have been compared but there was not a statistically significant difference (P = 0.526). Conclusions: Number of patients included in this search is higher than in the major part of the studies in literature. The results of the present study do not show any difference in term of ‘fatigue’ between a healthy control group and a group with history of breast cancer.
Prospective observational multicentric case-control study about 'fatigue' in patients with history of breast cancer
Gualandi Raffaella;Santini Daniele;Vincenzi Bruno;Rocci Laura;Tonini Giuseppe
2005-01-01
Abstract
Background: ‘Fatigue’ can persist for months or even for years after the end of treatment. Aims: Our study’s aim was to verify the presence of absence of ‘fatigue’ in women with history of breast cancer after 1–5 years from end of primary treatment and to assess the correlations between fatigue and some considered variables. Materials and Methods: Prospective observational multicentric case-control study. Inclusion criteria: history of non metastatic breast cancer; interval time from the end of treatment between 1 and 5 years, age over 18 years. Exclusion criteria: actual neoplastic disease, history of treatment for other types of tumor, any severe uncontrolled disease. Control sample: 100 women with no history of cancer or other severe uncontrolled diseases. Functional Assessment of Cancer Therapy-Fatigue (FACT-F) has been used to measure ‘Fatigue’. Results: 117 women with history of breast cancer. Median age: 60 years (37–83). 83 patients submitted to adjuvant chemo-therapy. Healthy sample: 100 women with median age of 58 years (34–78). A statistically significant difference in terms of fatigue between studied group and control group has been not observed (P = 0.652). On the contrary, a progressive and statistically significant reduction of fatigue levels has been observed in the studied group with the passing of time (P = 0.036). Besides, neither adjuvant chemo-therapy (P = 0.430) nor hormone-therapy (P = 0.296) have presented a correlation with ‘fatigue’. A correlation between age and ‘fatigue’ levels has not found (P = 0.282). Fatigue levels between women with nodal disease or without nodal disease have been compared but there was not a statistically significant difference (P = 0.526). Conclusions: Number of patients included in this search is higher than in the major part of the studies in literature. The results of the present study do not show any difference in term of ‘fatigue’ between a healthy control group and a group with history of breast cancer.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
