Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organiccompounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC andfor FeNO, official recommendations for standardised procedures are more than 10 years old and there isnone for exhaled VOCs and particles. The aim of this document is to provide technical standards andrecommendations for sample collection and analytic approaches and to highlight future research prioritiesin the field. For EBC and FeNO, new developments and advances in technology have been evaluated in thecurrent document. This report is not intended to provide clinical guidance on disease diagnosis andmanagement.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Publishedstudies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-basedmanner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions forresearch to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparableresults, thereby facilitating the potential use of these biomarkers in clinical practice.
A European respiratory society technical standard: Exhaled biomarkers in lung disease
Pennazza G.;Santonico M;
2017-01-01
Abstract
Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organiccompounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC andfor FeNO, official recommendations for standardised procedures are more than 10 years old and there isnone for exhaled VOCs and particles. The aim of this document is to provide technical standards andrecommendations for sample collection and analytic approaches and to highlight future research prioritiesin the field. For EBC and FeNO, new developments and advances in technology have been evaluated in thecurrent document. This report is not intended to provide clinical guidance on disease diagnosis andmanagement.Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Publishedstudies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-basedmanner by the Task Force members.Recommendations for standardisation of sampling, analysing and reporting of data and suggestions forresearch to cover gaps in the evidence have been created and summarised.Application of breath biomarker measurement in a standardised manner will provide comparableresults, thereby facilitating the potential use of these biomarkers in clinical practice.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
