Poorly Cohesive Carcinoma within Hyperplastic Polyp of the Stomach

A 75-year-old woman with a signet-ring cell carcinoma in a gastric hyperplastic polyp is reported. Endoscopic biopsies of the gastric lesion revealed glandular foveolar hyperplasia and ulceration, with focal severe cytological atypias in sparse glands. Total gastrectomy showed the presence of a polyp histologically characterized by hyperplastic glands and the presence of signet-ring cell carcinoma within the stroma. Cancer was limited to the polyp lesion. Extensive sampling of other regions of the stomach was negative for neoplasia. From a review of the literature, only 4 cases of signet ring carcinoma within a gastric hyperplastic polyp were reported. Our case points the focus on the relevance of extensive endoscopic sampling of hyperplastic polyps in order to rule out underlying neoplasia.