Fixed-bed adsorption on activated carbon is a common blood detoxification technique implemented in liver support devices to remove different types of toxins, among which is tryptophan. In this paper, fixed-bed adsorption kinetics of tryptophan on activated carbon were investigated. Experimental tryptophan breakthrough curves were obtained at different feed flow rates, both in albumin-free and albumin-containing solutions. A mathematical model based on linear driving force mass transfer kinetics was used to correlate data obtained with albumin-free solutions; subsequently, the results were successfully used to predict tryptophan breakthrough curves obtained with albumin-containing solutions, accounting only for the effect of albumin over tryptophan adsorption equilibrium. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
Removal of albumin-bound toxins from albumin-containing solutions: Tryptophan fixed-bed adsorption on activated carbon
PIEMONTE, Vincenzo;
2010-01-01
Abstract
Fixed-bed adsorption on activated carbon is a common blood detoxification technique implemented in liver support devices to remove different types of toxins, among which is tryptophan. In this paper, fixed-bed adsorption kinetics of tryptophan on activated carbon were investigated. Experimental tryptophan breakthrough curves were obtained at different feed flow rates, both in albumin-free and albumin-containing solutions. A mathematical model based on linear driving force mass transfer kinetics was used to correlate data obtained with albumin-free solutions; subsequently, the results were successfully used to predict tryptophan breakthrough curves obtained with albumin-containing solutions, accounting only for the effect of albumin over tryptophan adsorption equilibrium. (C) 2009 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
