Context: Magnesium deficiency is prevalent and increasingly recognized as an endocrine-relevant condition due to its involvement in hormone secretion, metabolic homeostasis, and cellular signaling. Objective: To review current evidence on the role of magnesium in key endocrine systems and evaluate its clinical and therapeutic implications. Evidence synthesis: Magnesium influences glucose metabolism, bone health, thyroid function, reproduction, cardiometabolic regulation, and HPA-axis activity. Clinical evidence shows strong associations between magnesium status and several endocrine diseases. Conclusion: Magnesium plays a multifaceted endocrine role with clinically significant implications. Improved diagnostic approaches and further interventional studies are warranted.
Magnesium as an Endocrine Modulator: Physiological Roles, Clinical Evidence, and Therapeutic Perspectives
Palermo, Andrea;Naciu, Anda Mihaela;Tabacco, Gaia;
2026-01-01
Abstract
Context: Magnesium deficiency is prevalent and increasingly recognized as an endocrine-relevant condition due to its involvement in hormone secretion, metabolic homeostasis, and cellular signaling. Objective: To review current evidence on the role of magnesium in key endocrine systems and evaluate its clinical and therapeutic implications. Evidence synthesis: Magnesium influences glucose metabolism, bone health, thyroid function, reproduction, cardiometabolic regulation, and HPA-axis activity. Clinical evidence shows strong associations between magnesium status and several endocrine diseases. Conclusion: Magnesium plays a multifaceted endocrine role with clinically significant implications. Improved diagnostic approaches and further interventional studies are warranted.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
