Fibers and Polyphenols in Diverticular Disease: From Pathophysiology to Management

Backgrounds: Diverticular disease, particularly symptomatic uncomplicated diverticular disease (SUDD), significantly impacts patient quality of life and is increasing in prevalence, especially in Western countries. While its pathophysiology is multifactorial, diet—specifically low fiber intake—has been implicated as a key modifiable factor in disease development and progression. Fibers influence colonic motility and stool composition, potentially reducing the formation of diverticula and symptom severity. Polyphenols, bioactive compounds with antioxidant and anti-inflammatory properties, may further protect intestinal integrity and modulate gut microbiota. Purpose: This narrative review explores emerging evidence on the role of dietary fiber and polyphenols in SUDD management. Despite promising mechanistic insights, current studies are limited by heterogeneity and methodological constraints. Personalized nutritional strategies focusing on fiber and polyphenol-rich foods warrant further investigation to optimize therapeutic outcomes in SUDD.