Effective administration of chemotherapeutics to the brain is a difficult task because of several reasons, including the anatomic location and the presence of the brain-to-blood barrier. The socio-economic burden of the pathology, discussed in the first part of the paper, stimulates the development of specific drug delivery systems, briefly reviewed and critically evaluated in a future perspective. Special emphasis is given to a solution under development at University Campus Bio-Medico (UCBM), which is compared to alternative approaches proposed in literature. Eventually, a technological roadmap is outlined and the related potential socio-economic impact is briefly discussed.
Technological and socio-economic implications in the development of implantable drug infusion systems for cancer therapy in tricky anatomic compartments: the case of brain tumours
ACCOTO D;Guglielmelli E
2010-01-01
Abstract
Effective administration of chemotherapeutics to the brain is a difficult task because of several reasons, including the anatomic location and the presence of the brain-to-blood barrier. The socio-economic burden of the pathology, discussed in the first part of the paper, stimulates the development of specific drug delivery systems, briefly reviewed and critically evaluated in a future perspective. Special emphasis is given to a solution under development at University Campus Bio-Medico (UCBM), which is compared to alternative approaches proposed in literature. Eventually, a technological roadmap is outlined and the related potential socio-economic impact is briefly discussed.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
