Background: Laser ablation with a neodymium:yttrium aluminum garnet (Nd:YAG) laser can achieve a high rateof complete tissue necrosis and has been applied as a minimally invasive, palliative option in hepatocellularcarcinoma, liver metastasis in colorectal cancer, and malignant thyroid nodules.Objective: To assess the in vivo feasibility of EUS-guided laser ablation with an Nd:YAG laser of normalpancreatic tissue of a porcine model.Design: Prospective investigation.Setting: Hospital animal laboratory.Subjects: Eight pigs.Interventions: EUS-guided puncture of the pancreatic tail with a laser-beam fiber. An Nd:YAG laser (1.064 nm)was used, with an output power of 2 and 3 W and a total delivered energy of 500 and 1000 J in continuous mode.Main Outcome Measurements: The 24-hour follow-up of the pigs was focused on clinical and laboratoryaspects. Results of histological studies of the pancreas were obtained 24 hours after the procedure on necroscopytissue.Results: There were no technical limitations to the performance of the procedure. Tissue necrosis, localized inthe pancreatic parenchyma, was observed in all animals on histological examination. The volume of ablationtissue ranged from a mean of 314 mm3 to 483 mm3. The ablation area ranged from a mean of 49 mm2 to 80 mm2.No major postprocedure complications were recorded, and all the pigs survived at 24 hours.Limitation: Animal study.Conclusions: EUS-guided laser ablation of the pancreas with an Nd:YAG laser is feasible in a porcine model.

EUS-guided Nd:YAG laser ablation of normal pancreatic tissue: a pilot study in a pig model

Di Matteo F;Pandolfi M;Rabitti C;Silvestri S;Valeri S;Coppola R;
2010-01-01

Abstract

Background: Laser ablation with a neodymium:yttrium aluminum garnet (Nd:YAG) laser can achieve a high rateof complete tissue necrosis and has been applied as a minimally invasive, palliative option in hepatocellularcarcinoma, liver metastasis in colorectal cancer, and malignant thyroid nodules.Objective: To assess the in vivo feasibility of EUS-guided laser ablation with an Nd:YAG laser of normalpancreatic tissue of a porcine model.Design: Prospective investigation.Setting: Hospital animal laboratory.Subjects: Eight pigs.Interventions: EUS-guided puncture of the pancreatic tail with a laser-beam fiber. An Nd:YAG laser (1.064 nm)was used, with an output power of 2 and 3 W and a total delivered energy of 500 and 1000 J in continuous mode.Main Outcome Measurements: The 24-hour follow-up of the pigs was focused on clinical and laboratoryaspects. Results of histological studies of the pancreas were obtained 24 hours after the procedure on necroscopytissue.Results: There were no technical limitations to the performance of the procedure. Tissue necrosis, localized inthe pancreatic parenchyma, was observed in all animals on histological examination. The volume of ablationtissue ranged from a mean of 314 mm3 to 483 mm3. The ablation area ranged from a mean of 49 mm2 to 80 mm2.No major postprocedure complications were recorded, and all the pigs survived at 24 hours.Limitation: Animal study.Conclusions: EUS-guided laser ablation of the pancreas with an Nd:YAG laser is feasible in a porcine model.
EUS-guided laser ablation; Laser ablation with Nd:YAG
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12610/8444
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