IRIS
MENNA, PIERANTONIO
 Distribuzione geografica
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Continente #
AS - Asia 4.019
NA - Nord America 668
EU - Europa 372
SA - Sud America 21
OC - Oceania 12
AF - Africa 9
Totale 5.101
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Nazione #
SG - Singapore 3.227
US - Stati Uniti d'America 630
CN - Cina 443
HK - Hong Kong 290
GB - Regno Unito 102
DE - Germania 78
CZ - Repubblica Ceca 54
IT - Italia 42
FI - Finlandia 25
CA - Canada 23
IN - India 23
NL - Olanda 17
BR - Brasile 15
AU - Australia 12
MX - Messico 12
PL - Polonia 9
ZA - Sudafrica 9
JP - Giappone 8
BE - Belgio 6
FR - Francia 6
UA - Ucraina 6
TR - Turchia 5
ID - Indonesia 4
TW - Taiwan 4
AT - Austria 3
EE - Estonia 3
LT - Lituania 3
PT - Portogallo 3
SE - Svezia 3
AE - Emirati Arabi Uniti 2
AL - Albania 2
AR - Argentina 2
CL - Cile 2
ES - Italia 2
GE - Georgia 2
IE - Irlanda 2
PK - Pakistan 2
BA - Bosnia-Erzegovina 1
BD - Bangladesh 1
BG - Bulgaria 1
BY - Bielorussia 1
CO - Colombia 1
DK - Danimarca 1
DM - Dominica 1
DO - Repubblica Dominicana 1
EC - Ecuador 1
IL - Israele 1
IQ - Iraq 1
KR - Corea 1
KZ - Kazakistan 1
LK - Sri Lanka 1
PA - Panama 1
PH - Filippine 1
RO - Romania 1
RU - Federazione Russa 1
SA - Arabia Saudita 1
YE - Yemen 1
Totale 5.101
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Città #
Hong Kong 288
Singapore 216
Hefei 183
Ashburn 149
Boardman 106
Beijing 86
London 82
Shanghai 59
Munich 48
Brno 35
Los Angeles 34
Dallas 28
Council Bluffs 27
Rome 26
San Francisco 26
Redmond 20
Olomouc 17
Pune 17
Amsterdam 16
Turku 14
Seattle 12
Guangzhou 11
Helsinki 11
Santa Clara 11
Washington 11
Mexico City 10
Toronto 10
Boston 9
New York 9
São Paulo 9
Manchester 8
Brooklyn 7
Tokyo 7
Warsaw 7
Melbourne 6
Chicago 5
Haikou 4
Johannesburg 4
Montreal 4
Ankara 3
Atlanta 3
Canberra 3
Chennai 3
Hangzhou 3
Hanover 3
Mol 3
Oklahoma City 3
Paris 3
Stockholm 3
Sydney 3
Taipei 3
Wuhan 3
Aversa 2
Concord 2
Dublin 2
Genoa 2
Grand Rapids 2
Hasselt 2
Iowa City 2
Lodz 2
Luoyang 2
New Delhi 2
North Liberty 2
Nuremberg 2
Phoenix 2
Porto 2
Shanwei 2
Shenzhen 2
Tallinn 2
Tbilisi 2
The Dalles 2
Tirana 2
Topeka 2
Vilnius 2
West Jordan 2
Xiamen 2
Zhengzhou 2
Almaty 1
Ansan-si 1
Augusta 1
Berlin 1
Birmingham 1
Bismarck 1
Brussels 1
Buenos Aires 1
Cartagena 1
Central District 1
Centurion 1
Changchun 1
Changsha 1
Charlotte 1
Chengdu 1
Chongqing 1
Clarksburg 1
Clifton 1
Colombo 1
Columbia 1
Dalian 1
David 1
Denver 1
Totale 1.744
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Nome #
Cardiovascular safety of anti-TNF-alpha therapies: Facts and unsettled issues. 196
Anthracyclines and Cardiotoxicity: Is CARP a Forgotten Biomarker? 182
Cancer drugs and QT prolongation: weighing risk against benefit 182
Choosing Antifungals for the Midostaurin-Treated Patient: Does CYP3A4 Outweigh Recommendations? A Brief Insight from Real Life 182
Doxorubicinolone formation and efflux : A salvage pathway against epirubicin accumulation in human heart 173
The endogenous lusitropic and chronotropic agent, B-type natriuretic peptide, limits cardiac troponin release in cancer patients with an early impairment of myocardial relaxation induced by anthracyclines 171
Minimal sampling colistin pharmacokinetics in critically ill patients 170
Cardiovascular toxicity of antitumor drugs :Translating molecular mechanisms into clinical facts 168
Pharmacology of Ranolazine versus Common Cardiovascular Drugs in Patients with Early Diastolic Dysfunction Induced by Anthracyclines or Nonanthracycline Chemotherapeutics: A Phase 2b Minitrial 168
Cardio-oncology in clinical studies and real life 166
Defective taxane stimulation of epirubicinol formation in the human heart: Insights into the cardiac tolerability of epirubicin-taxane chemotherapies 161
Altered iron regulatory protein activities in doxorubicin-treated cardiomyocytes : Distinct roles of reactive oxygen species and of the secondary alcohol metabolite doxorubicinol 157
4’- Epidoxorubicin to reexplore anthracycline degradation in cardiomyocytes 152
Chronic cardiotoxicity of anticancer anthracyclines in the rat: role of secondary metabolites and reduced toxicity by a novel anthracycline with impaired metabolite formation and reactivity 135
Beyond hypertension: Diastolic dysfunction associated with cancer treatment in the era of cardio-oncology 115
Pharmacology of cardio-oncology: chronotropic and lusitropic effects of B-type natriuretic peptide in cancer patients with early diastolic dysfunction induced by anthracycline or nonanthracycline chemotherapy 104
Anthracyclines 103
Anthracycline Cardiotoxicity 100
Early Diastolic Dysfunction after Cancer Chemotherapy: Primary Endpoint Results of a Multicenter Cardio-Oncology Study 98
Anthracycline metabolism and toxicity in human myocardyum: Comparisons between doxorubicin, epirubicin, and a novel disaccaride analogue with redeced formation and [4Fe-4S]-reactivity of its secondary alchol metabolite 97
Anthracycline degradation in cardiomyocytes: a journey to oxidative survival 94
Anthracycline Cardiotoxicity 87
Defective one or two electron reduction of the anticancer anthracycline epirubicin in human heart: Relative importance of vesicular sequestration and impaired efficiency of electron addition 83
An introduction to the metabolic determinants of anthracycline cardiotoxicity 77
Cardiotoxicity of antitumor drugs 72
Cardiotoxicity of targeted cancer drugs: concerns, “The cart before the horse,” and lessons from trastuzumab 67
Low dose anthracycline and risk of heart failure in a pharmacokinetic model of human myocardium exposure: analog specificity and role of secondary alcohol metabolites 66
CARDIAC ANTHRACYCLINE ACCUMULATION AND B-TYPE NATRIURETIC PEPTIDE TO DEFINE RISK AND PREDICTORS OF CANCER TREATMENT RELATED EARLY DIASTOLIC DYSFUNCTION 61
Anthracyclines, diastolic dysfunction and the road to heart failure in Cancer survivors: An untold story 45
Anthracyclines: molecular advances and pharmacological developments in antitumor activity and cardiotoxicity 44
What is cardiotoxicity? 42
From Cardiac Anthracycline Accumulation to Real-Life Risk for Early Diastolic Dysfunction: A Translational Approach 36
Doxorubicin-Dependent Reduction of Ferrylmyoglobin and Inhibition of Lipid Peroxidation: Implications for Cardiotoxicity of Anticancer Anthracyclines 36
Isavuconazole: case report and pharmacokinetic considerations 36
Further analytical, pharmacokinetic, and clinical observations on low-dose ponatinib in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia 36
Modeling human myocardium exposure to doxorubicin defines the risk of heart failure from low-dose doxorubicin 35
Pharmacokinetics of pegylated liposomal doxorubicin administered by intraoperative hyperthermic intraperitoneal chemotherapy to patients with advanced ovarian cancer and peritoneal carcinomatosis 34
Paclitaxel and docetaxel enhance the metabolism of doxorubicin to toxic species in human myocardium 33
Pharmacology of Cardio-Oncology 33
Safety and tolerability of a novel oral nutritional supplement in healthy volunteers 33
NEW TARGETED DRUGS FOR ACUTE MYELOID LEUKEMIA AND ANTIFUNGALS: PHARMACOKINETIC CHALLENGES AND OPPORTUNITIES 32
Paclitaxel and docetaxel stimulation of doxorubicinol formation in the human heart: Implications for cardiotoxicity of doxorubicin-taxane chemotherapies 32
Oxidative degradation of cardiotoxic anticancer anthracyclines to phthalic acids. Novel function or ferrylmyoglobin 31
Doxorubicin irreversibly inactivates Iron Regulatory Proteins 1 and 2 in cardiomyocytes : Evidence for distinct metabolic pathways and implications for iron-mediated cardiotoxicity of antitumor therapy 31
Advances in Bruton tyrosine kinase (Btk) inhibition are steered by Bruton tyrosine kinase phylogeny 30
Low level tumor necrosis factor-alpha protects cardiomyocytes against high level tumor necrosis factor-alpha: brief insight into a beneficial paradox 29
The concomitant management of cancer therapy and cardiac therapy 29
Predictors of early or delayed diastolic dysfunction after anthracycline-based or nonanthracycline chemotherapy: a pharmacological appraisal 29
The novel anthracenedione, pixantrone, lacks redox activity and inhibits doxorubicinol formation in human myocardium: Insight to explain the cardiac safety of pixantrone in doxorubicin treated patients 27
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model II. Amrubicin shows metabolic advantages over doxorubicin and epirubicin 27
Rethinking drugs from chemistry to therapeutic opportunities: Pixantrone beyond Anthracyclines. 27
MEN 10755 : A novel disaccharide anthracycline with a reduced level of formation and [4Fe-4S]-reactivity of toxic alcohol metabolite in human heart . 26
Pharmacological Foundation of Cardio-Oncology 25
Matters of the heart: The case of TNF-alpha targeting drugs 25
Managing anthracycline-induced cardiotoxicity: beginning with the end in mind 25
Telaprevir raises the plasma/whole blood ribavirin ratio: trying to come full circle on a dangerous relationship 25
Doxorubicin metabolism to toxic species in human myocardium: stimulation by paclitaxel and docetaxel but not BMS 184476 or BMS 188797 25
Development and Validation of a UHPLC-MS/MS-Based Method to Quantify Cenobamate in Human Plasma Samples 24
Pharmacokinetic characterization of amrubicin cardiac safety in an ex vivo human myocardial strip model I Amrubicin accumulates to a lower level than doxorubicin or epirubicin 24
MEN 10755: a novel disaccaride anthracycline with a reduced level of formation and [4Fe-4S]- reactivity of toxic alcohol metabolite in human myocardium 24
Doxorubicin degradation in cardiomyocytes 23
Impairment of myocardial contractility by anticancer anthracyclines: role of secondary alcohol metabolites and evidence of reduced toxicity by a novel disaccharide analogue 22
In vitro modelling of the structure-activity determinants of anthracycline cardiotoxicity. 22
Ferrylmyoglobin-dependent oxidative degradation of doxorubicin: a novel pathway of anthracycline metabolism and toxicity 22
Doxorubicin dependent reduction of hypervalent ferrylmyoglobin: One more evidence against the oxidative nature of doxorubicin-induced cardiotoxicity 22
Ibrutinib and Bruton's tyrosine kinase inhibitors in chronic lymphocytic leukemia: focus on atrial fibrillation and ventricular tachyarrhythmias/sudden cardiac death 22
Primary prevention strategies for anthracycline cardiotoxicity: a brief overview 21
Efficacy and safety of low dose ponatinib in a case of Ph-positive acute lymphoblastic leukaemia 21
Tumour necrosis factor alpha (TNFα)cardiomyocyte preconditioning: clues to explain anti-TNFα agents contraindication in severe heart failure 21
Translating molecular mechanisms into clinical facts 21
Doxorubicin inhibits ferrylmyoglobin-dependent lipid peroxidation 21
Posaconazole and midostaurin in patients with FLT3-mutated acute myeloid leukemia: Pharmacokinetic interactions and clinical facts in a real life study 20
In ®Entresto we trust 20
Increasing doxorubicin antitumor activity through COX-2 inhibition without increasing cardiotoxicity 20
Taxanes stimolate Doxorubicin conversion to its cardiotoxic secondary alcohol metabolite doxorubicinol: studies in human myocardium 20
Taxanes stimulate doxorubicin conversion to its cardiotoxic secondary alcohol metabolite : Studies in human myocardium. 20
Role of secondary alcohol metabolites in anthracycline cardiotoxicity: from hypotheses to new drugs 19
Modified colistin regimen for critically ill patients with acute renal impairment and continuous renal replacement therapy 19
The use of pegylated liposomal doxorubicin with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients undergoing cytoreductive surgery (CS) for peritoneal carcinomatosis of ovarian origin 19
Molecular determinants of the reduced cardiotoxicity of epirubicin 19
The novel anthracycline MEN 10755 is less cardiotoxic than doxorubicin or epirubicin due to reduced formation and aconitase-reactivity its secondary alcohol metabolite 19
Tnf-alpha induced cardioprotection: effects on reactive oxygen species (ros) and apoptosis 19
Tumor necrosis factor alpha and cardiomyocytes: evidence for a self-protective preconditioning 18
Recommendations for the harmonization of reference intervals in the therapeutic monitoring of antiepileptic drugs/Indicazioni per l’armonizzazione degli intervalli di riferimento nel monitoraggio terapeutico di farmaci antiepilettici 17
Do you know pixantrone? 17
Defective one or two electron reduction of the anticancer anthracycline epirubicin in human heart: relative importance of vesicular sequestration and impaired efficiency of electron addition J. Biol. Chem 17
Doxorubicin Cardiotoxicity and the Control of Iron Metabolism: Quinone-Dependent and Independent Mechanisms 17
Pixantrone (PIX) Inhibition of Doxorubicinol (DOXOL) Formation in Human Myocardium: Implications for Cardiac Safety in Non-Hodgkin Lymphoma (NHL) Patients with Prior Anthracycline Treatment 16
Correction: Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN) 16
Quantitative Analysis of Cenobamate and Concomitant Anti-Seizure Medications in Human Plasma via Ultra-High Performance Liquid Chromatography–Tandem Mass Spectrometry 16
The reality of pixantrone in real life 15
Humans and Rodents: The Case of hOAT4 and mOat5 12
High Incidence of Invasive Fungal Diseases in Patients with FLT3-Mutated AML Treated with Midostaurin: Results of a Multicenter Observational SEIFEM Study 11
Infectious complications of targeted drugs and biotherapies in acute leukemia. Clinical practice guidelines by the European Conference on Infections in Leukemia (ECIL), a joint venture of the European Group for Blood and Marrow Transplantation (EBMT), the European Organization for Research and Treatment of Cancer (EORTC), the International Immunocompromised Host Society (ICHS) and the European Leukemia Net (ELN) 3
Totale 5.204
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Categoria #
all - tutte 38.567
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 38.567
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/2022218 0 4 0 0 0 0 1 92 4 0 5 112
2022/202356 2 1 1 4 2 2 15 0 3 3 22 1
2023/2024333 6 35 11 15 37 146 1 16 2 8 4 52
2024/20254.043 102 36 123 15 45 77 40 21 250 263 1.446 1.625
2025/2026554 336 204 14 0 0 0 0 0 0 0 0 0
Totale 5.204